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李高参

职称职务:助理研究员

专业:生物医学工程

电话:13540813678

电子邮箱:gaocanli@scu.edu.cn

个人简历:

2014.05-至今 四川大学,生物材料工程研究中心,助理研究员

2008.09-2013.07 四川大学,化学学院,理学博士

2003.09-2007.07 四川大学,化学学院,理学学士

主要工作业绩:

主要从事基于鎓盐的新型生物医用材料的开发,主要包括智能纳米药物/基因传输系统、荧光标记材料以及多功能刺激响应材料等, 在生物标记,新型纳米囊泡构筑以及多功能刺激响应材料等方面取得了一系列创新性成果。近年来,在JACS、Nature Commun.、Angew. Chem. Int. Ed.、Adv. Funct. Mater.等国际权威刊物发表论文10余篇。

主要研究方向:

1. 智能纳米药物/基因传输系统的构建

2. 亚细胞结构荧光标记材料的开发

3. 生物力学响应材料的开发

主要在研项目:

1. 国家自然科学基金青年基金(21502129),主持

2. 四川大学青年科研启动基金(2015SCU11039),主持

3. 国家重点研发计划(2016YFC1102201),分课题负责人

4. “863”项目(2015AA034202),课题骨干

近期研究成果:

1. Gaocan Li, Yangyang Xu, Weihua Zhuang and Yunbing Wang, Preparation of organic mechanochromic fluorophores with simple structures and promising mechanochromic luminescence properties, RSC Adv., 2016, 6, 84787.

2. Gaocan Li, Ke Yang, Jing Sun and Yunbing Wang, Highly specific probe for dual-emissive mitochondrial imaging based on a photostable and aqueous-soluble phosphonium fluorophore, RSC Adv., 2016, 6, 94085.

3. Yangyang Cheng, Gaocan Li, Yang Liu, Yang Shi, Ge Gao, Di Wu, Jingbo Lan, and Jingsong You, Unparalleled Ease of Access to a Library of Biheteroaryl Fluorophores via Oxidative Cross-Coupling Reactions: Discovery of Photostable NIR Probe for Mitochondria, J. Am. Chem. Soc., 2016, 138, 4730.

4. Gaocan Li, Shiyong Zhang, Ningjie Wu, Yangyang Cheng, and Jingsong You, Spontaneous Counterion-Induced Vesicle Formation: Multivalent Binding to Europium(III) for a Wide-Range Optical pH Sensor, Adv. Funct. Mater. 2014, 24, 6204.

5. Gaocan Li, Feijie Song, Di Wu, Jingbo Lan, Xingyan Liu, Jie Wu, Shuaijun Yang, Dan Xiao, and Jingsong You, Cation–Anion Interaction-Directed Molecular Design Strategy for Mechanochromic Luminescence, Adv. Funct. Mater. 2014, 24, 747.

6. Xingyan Liu, Gaocan Li, Feijie Song and Jingsong You, Unexpected regioselective carbon–hydrogen bond activation/cyclization of indolyl aldehydes or ketones with alkynes to benzo-fused oxindoles, Nat. Commun. 2014, 5, 5030.

7. Yumin Huang, Gaocan Li, Jingsheng Huang, and Jingsong You, Palladium-catalyzed direct ortho-C–H ethoxycarboxylation of anilides at room temperature, Org. Chem. Front. 2014, 1, 347.

8. Gaocan Li, Shengyou Qian, Chunxia Wang, and Jingsong You, Palladium(II)-Catalyzed Dehydrogenative Cross-Coupling between Two Csp3-H Bonds: Unexpected C=C Bond Formation, Angew. Chem. Int. Ed. 2013, 52, 7837.

9. Dongbing Zhao, Gaocan Li, Di Wu, Xurong Qin, Patrik Neuhaus, Yangyang Cheng, Shuaijun Yang, Zhiyun Lu, Xuemei Pu, Chao Long, and Jingsong You, Regiospecific N-Heteroarylation of Amidines for Full-Color-Tunable Boron Difluoride Dyes with Mechanochromic Luminescence, Angew. Chem. Int. Ed. 2013, 52, 13676.

10. Liangbo Zhu, Gaocan Li, Liang Luo, Peng Guo, Jingbo Lan, and Jingsong You, Highly Functional Group Tolerance in Copper-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles under Mild Conditions, J. Org. Chem. 2009, 74, 2200.

11. Liangbo Zhu, Peng Guo, Gaocan Li, Jingbo Lan, Rugang Xie, and Jingsong You, Simple Copper Salt-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles with Aryl and Heteroaryl Halides, J. Org. Chem. 2007, 72, 8535.

 
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